| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-05 | at Central Michigan (60) | 20-13 | Won | 0.1090 | 0.8771 |
| 17-Sep-05 | vs Kentucky (86) | 38-14 | Won | -0.6976 | 0.0705 |
| 01-Oct-05 | at Wisconsin (10) | 24-41 | Lost | 1.5327 | 0.0000 |
| 08-Oct-05 | vs Illinois (66) | 36-13 | Won | -0.2626 | 0.5055 |
| 15-Oct-05 | at Iowa (21) | 21-38 | Lost | 1.2327 | 0.0000 |
| 22-Oct-05 | vs Ohio State (4) | 10-41 | Lost | 1.8592 | 0.0000 |
| 29-Oct-05 | at Michigan St (37) | 15-46 | Lost | 0.7215 | -0.5104 |
| 05-Nov-05 | vs Minnesota (18) | 21-42 | Lost | 1.0026 | -0.2292 |
| 12-Nov-05 | at Michigan (12) | 14-41 | Lost | 1.5040 | 0.0000 |
| 19-Nov-05 | vs Purdue (34) | 14-41 | Lost | 0.5219 | -0.7100 |
A red opponent rating indicates modification according to home field advantage (0.1322).