| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Bowling Green (85) | 56-42 | Won | -0.6558 | -0.0000 |
| 10-Sep-05 | vs Temple (107) | 65-0 | Won | -1.4973 | -0.0000 |
| 17-Sep-05 | at North Carolina (36) | 14-5 | Won | 0.7274 | 0.3270 |
| 24-Sep-05 | vs Michigan (12) | 23-20 | Won | 1.2396 | 0.8391 |
| 01-Oct-05 | vs Indiana (47) | 41-24 | Won | 0.0997 | -0.0000 |
| 08-Oct-05 | at Northwestern (15) | 48-51 | Lost | 1.4361 | -0.9644 |
| 15-Oct-05 | at Minnesota (18) | 38-34 | Won | 1.2671 | 0.8666 |
| 22-Oct-05 | vs Purdue (34) | 31-20 | Won | 0.5219 | 0.1214 |
| 29-Oct-05 | at Illinois (66) | 41-24 | Won | 0.0018 | -0.0000 |
| 05-Nov-05 | at Penn State (3) | 14-35 | Lost | 2.2836 | -0.1169 |
| 12-Nov-05 | vs Iowa (21) | 10-20 | Lost | 0.9682 | -1.0000 |
| 25-Nov-05 | at Hawai`i (89) | 41-24 | Won | -0.4761 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1322).