| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Ball St (80) | 56-0 | Won | -0.5457 | -0.0000 |
| 10-Sep-05 | at Iowa St (39) | 3-23 | Lost | 0.5827 | -1.0000 |
| 24-Sep-05 | at Ohio State (4) | 6-31 | Lost | 2.1236 | 0.0000 |
| 01-Oct-05 | vs Illinois (66) | 35-7 | Won | -0.2626 | -0.0000 |
| 08-Oct-05 | at Purdue (34) | 34-17 | Won | 0.7863 | 0.6859 |
| 15-Oct-05 | vs Indiana (47) | 38-21 | Won | 0.0997 | -0.0000 |
| 22-Oct-05 | vs Michigan (12) | 20-23 | Lost | 1.2396 | -0.8609 |
| 05-Nov-05 | at Northwestern (15) | 27-28 | Lost | 1.4361 | -0.6644 |
| 12-Nov-05 | at Wisconsin (10) | 20-10 | Won | 1.5327 | 1.0000 |
| 19-Nov-05 | vs Minnesota (18) | 52-28 | Won | 1.0026 | 0.9022 |
A red opponent rating indicates modification according to home field advantage (0.1322).