| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 01-Sep-05 | at Tulsa (51) | 41-10 | Won | 0.3002 | 0.1653 |
| 10-Sep-05 | vs Colorado St (53) | 56-24 | Won | -0.0018 | -0.0000 |
| 17-Sep-05 | vs Florida Atlantic (116) | 46-7 | Won | -2.1887 | -0.0000 |
| 24-Sep-05 | vs Purdue (34) | 42-35 | Won | 0.5219 | 0.3870 |
| 01-Oct-05 | at Penn State (3) | 14-44 | Lost | 2.2836 | 0.0000 |
| 08-Oct-05 | at Michigan (12) | 23-20 | Won | 1.5040 | 1.0000 |
| 15-Oct-05 | vs Wisconsin (10) | 34-38 | Lost | 1.2683 | -0.8666 |
| 29-Oct-05 | vs Ohio State (4) | 31-45 | Lost | 1.8592 | -0.2756 |
| 05-Nov-05 | at Indiana (47) | 42-21 | Won | 0.3641 | 0.2292 |
| 12-Nov-05 | vs Michigan St (37) | 41-18 | Won | 0.4571 | 0.3222 |
| 19-Nov-05 | at Iowa (21) | 28-52 | Lost | 1.2327 | -0.9022 |
A red opponent rating indicates modification according to home field advantage (0.1322).