| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-05 | vs Indiana (47) | 13-20 | Lost | 0.0997 | -0.8771 |
| 10-Sep-05 | at Miami OH (71) | 38-37 | Won | -0.1144 | 0.9088 |
| 17-Sep-05 | at Penn State (3) | 3-40 | Lost | 2.2836 | 0.0000 |
| 24-Sep-05 | vs Eastern Michigan (97) | 20-23 | Lost | -1.0904 | -1.0000 |
| 01-Oct-05 | at Akron (78) | 31-17 | Won | -0.2383 | 0.7849 |
| 08-Oct-05 | at Army (91) | 14-10 | Won | -0.5004 | 0.5229 |
| 15-Oct-05 | vs Ohio U. (93) | 37-10 | Won | -0.9384 | 0.0848 |
| 29-Oct-05 | vs Toledo (62) | 21-17 | Won | -0.1886 | 0.8346 |
| 05-Nov-05 | vs Northern Illinois (56) | 28-31 | Lost | -0.0298 | -1.0000 |
| 12-Nov-05 | at Western Michigan (72) | 24-31 | Lost | -0.1228 | -1.0000 |
| 19-Nov-05 | at Ball St (80) | 31-24 | Won | -0.2813 | 0.7419 |
A red opponent rating indicates modification according to home field advantage (0.1322).