| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | at Ohio State (4) | 14-34 | Lost | 2.1236 | 0.0000 |
| 10-Sep-05 | vs Central Michigan (60) | 37-38 | Lost | -0.1554 | -0.9088 |
| 17-Sep-05 | at Kent St (119) | 27-10 | Won | -2.8632 | -0.0000 |
| 28-Sep-05 | vs Cincinnati (82) | 44-16 | Won | -0.5816 | 0.6650 |
| 05-Oct-05 | at Northern Illinois (56) | 27-38 | Lost | 0.2346 | -0.5188 |
| 15-Oct-05 | vs Akron (78) | 51-23 | Won | -0.5027 | 0.7439 |
| 22-Oct-05 | at Eastern Michigan (97) | 24-23 | Won | -0.8260 | 0.4206 |
| 29-Oct-05 | at Temple (107) | 41-14 | Won | -1.2329 | 0.0137 |
| 05-Nov-05 | vs Buffalo (115) | 54-13 | Won | -2.1499 | -0.0000 |
| 15-Nov-05 | vs Bowling Green (85) | 14-42 | Lost | -0.6558 | -1.0000 |
| 21-Nov-05 | at Ohio U. (93) | 38-7 | Won | -0.6740 | 0.5726 |
A red opponent rating indicates modification according to home field advantage (0.1322).