| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 01-Sep-05 | vs Eastern Michigan (97) | 28-26 | Won | -1.0904 | 0.3590 |
| 10-Sep-05 | at Penn State (3) | 24-42 | Lost | 2.2836 | 0.0000 |
| 28-Sep-05 | at Miami OH (71) | 16-44 | Lost | -0.1144 | -0.6650 |
| 08-Oct-05 | at Pittsburgh (63) | 20-38 | Lost | 0.0700 | -0.4806 |
| 15-Oct-05 | vs Connecticut (81) | 28-17 | Won | -0.5704 | 0.8790 |
| 22-Oct-05 | vs Louisville (30) | 22-46 | Lost | 0.5977 | 0.0000 |
| 29-Oct-05 | at Syracuse (105) | 22-16 | Won | -1.1999 | 0.2495 |
| 09-Nov-05 | vs West Virginia (17) | 0-38 | Lost | 1.0880 | 0.0000 |
| 19-Nov-05 | at South Florida (43) | 16-31 | Lost | 0.5007 | -0.0499 |
| 26-Nov-05 | at Rutgers (55) | 9-44 | Lost | 0.2402 | -0.3105 |
A red opponent rating indicates modification according to home field advantage (0.1322).