| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 04-Sep-05 | vs West Virginia (17) | 7-15 | Lost | 1.0880 | 0.0000 |
| 10-Sep-05 | vs Buffalo (115) | 31-0 | Won | -2.1499 | 0.1823 |
| 17-Sep-05 | vs Virginia (40) | 24-27 | Lost | 0.3175 | 0.0000 |
| 01-Oct-05 | at Florida St (29) | 14-38 | Lost | 0.9323 | 0.0000 |
| 07-Oct-05 | at Connecticut (81) | 7-26 | Lost | -0.3060 | 0.0000 |
| 15-Oct-05 | vs Rutgers (55) | 9-31 | Lost | -0.0243 | 0.0000 |
| 22-Oct-05 | at Pittsburgh (63) | 17-34 | Lost | 0.0700 | 0.0000 |
| 29-Oct-05 | vs Cincinnati (82) | 16-22 | Lost | -0.5816 | -0.2495 |
| 12-Nov-05 | vs South Florida (43) | 0-27 | Lost | 0.2363 | 0.0000 |
| 19-Nov-05 | at Notre Dame (6) | 10-34 | Lost | 1.8496 | 0.0000 |
| 26-Nov-05 | at Louisville (30) | 17-41 | Lost | 0.8621 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1322).