| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | vs Notre Dame (6) | 21-42 | Lost | 1.5852 | 0.0000 |
| 09-Sep-05 | at Ohio U. (93) | 10-16 | Lost | -0.6740 | -1.0000 |
| 17-Sep-05 | at Nebraska (35) | 6-7 | Lost | 0.7408 | -0.1970 |
| 30-Sep-05 | at Rutgers (55) | 29-37 | Lost | 0.2402 | -0.6976 |
| 08-Oct-05 | vs Cincinnati (82) | 38-20 | Won | -0.5816 | 0.4806 |
| 15-Oct-05 | vs South Florida (43) | 31-17 | Won | 0.2363 | 1.0000 |
| 22-Oct-05 | vs Syracuse (105) | 34-17 | Won | -1.4644 | -0.0000 |
| 03-Nov-05 | at Louisville (30) | 20-42 | Lost | 0.8621 | -0.0757 |
| 12-Nov-05 | vs Connecticut (81) | 24-0 | Won | -0.5704 | 0.4918 |
| 24-Nov-05 | at West Virginia (17) | 13-45 | Lost | 1.3524 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1322).