| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 03-Sep-05 | at Penn State (3) | 13-23 | Lost | 2.2836 | 0.0000 |
| 17-Sep-05 | vs Central Florida (65) | 31-14 | Won | -0.2514 | 0.3801 |
| 24-Sep-05 | vs Louisville (30) | 45-14 | Won | 0.5977 | 1.0000 |
| 01-Oct-05 | at Miami FL (13) | 7-27 | Lost | 1.4502 | 0.0000 |
| 15-Oct-05 | at Pittsburgh (63) | 17-31 | Lost | 0.0700 | -1.0000 |
| 05-Nov-05 | at Rutgers (55) | 45-31 | Won | 0.2402 | 0.8717 |
| 12-Nov-05 | at Syracuse (105) | 27-0 | Won | -1.1999 | -0.0000 |
| 19-Nov-05 | vs Cincinnati (82) | 31-16 | Won | -0.5816 | 0.0499 |
| 26-Nov-05 | at Connecticut (81) | 10-15 | Lost | -0.3060 | -1.0000 |
| 03-Dec-05 | vs West Virginia (17) | 13-28 | Lost | 1.0880 | -0.2805 |
A red opponent rating indicates modification according to home field advantage (0.1322).