| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Northwestern (78) | 3-21 | Lost | -0.7172 | -0.1850 |
| 09-Sep-06 | at Purdue (40) | 31-38 | Lost | 0.7291 | 0.0000 |
| 16-Sep-06 | vs Kent St (94) | 14-16 | Lost | -1.2034 | -0.6712 |
| 23-Sep-06 | at Syracuse (70) | 14-34 | Lost | -0.0669 | 0.0000 |
| 30-Sep-06 | at Cincinnati (37) | 10-24 | Lost | 0.7802 | 0.0000 |
| 08-Oct-06 | vs Northern Illinois (81) | 25-28 | Lost | -0.7402 | -0.2080 |
| 15-Oct-06 | at Buffalo (115) | 38-31 | Won | -1.6410 | 0.8912 |
| 21-Oct-06 | at Akron (102) | 13-24 | Lost | -0.9147 | -0.3825 |
| 28-Oct-06 | vs Ball St (89) | 17-20 | Lost | -1.0092 | -0.4770 |
| 04-Nov-06 | at Western Michigan (64) | 24-27 | Lost | 0.0337 | 0.0000 |
| 15-Nov-06 | at Bowling Green (112) | 9-7 | Won | -1.5480 | 0.9842 |
| 24-Nov-06 | vs Ohio U. (49) | 24-34 | Lost | -0.1696 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2218).