| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (1) | 12-35 | Lost | 3.7926 | 0.0000 |
| 09-Sep-06 | vs Ohio U. (49) | 23-35 | Lost | -0.1696 | -0.6512 |
| 16-Sep-06 | vs Buffalo (115) | 31-13 | Won | -2.0846 | -0.0000 |
| 30-Sep-06 | at Ball St (89) | 40-28 | Won | -0.5655 | 0.9528 |
| 08-Oct-06 | at Miami OH (109) | 28-25 | Won | -1.3103 | 0.2080 |
| 14-Oct-06 | at Western Michigan (64) | 14-16 | Lost | 0.0337 | -0.4479 |
| 21-Oct-06 | vs Temple (116) | 43-21 | Won | -2.1469 | -0.0000 |
| 28-Oct-06 | at Iowa (48) | 14-24 | Lost | 0.3285 | -0.1531 |
| 07-Nov-06 | vs Toledo (104) | 13-17 | Lost | -1.4333 | -1.0000 |
| 17-Nov-06 | vs Central Michigan (63) | 31-10 | Won | -0.4065 | 1.0000 |
| 24-Nov-06 | at Eastern Michigan (111) | 27-0 | Won | -1.4433 | 0.0751 |
A red opponent rating indicates modification according to home field advantage (0.2218).