| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (70) | 20-13 | Won | -0.0669 | 0.8265 |
| 16-Sep-06 | vs Iowa St (96) | 27-17 | Won | -1.2256 | -0.0000 |
| 23-Sep-06 | at Illinois (98) | 24-7 | Won | -0.7988 | 0.0946 |
| 30-Sep-06 | vs Ohio State (1) | 17-38 | Lost | 3.3490 | 0.0000 |
| 07-Oct-06 | vs Purdue (40) | 47-17 | Won | 0.2855 | 1.0000 |
| 14-Oct-06 | at Indiana (47) | 28-31 | Lost | 0.3773 | -0.7294 |
| 21-Oct-06 | at Michigan (2) | 6-20 | Lost | 3.1274 | 0.0000 |
| 28-Oct-06 | vs Northern Illinois (81) | 24-14 | Won | -0.7402 | 0.1531 |
| 04-Nov-06 | vs Northwestern (78) | 7-21 | Lost | -0.7172 | -1.0000 |
| 11-Nov-06 | vs Wisconsin (6) | 21-24 | Lost | 1.9353 | 0.0000 |
| 18-Nov-06 | at Minnesota (39) | 24-34 | Lost | 0.7653 | -0.3414 |
A red opponent rating indicates modification according to home field advantage (0.2218).