| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Vanderbilt (60) | 27-7 | Won | -0.2862 | -0.0000 |
| 09-Sep-06 | vs Central Michigan (63) | 41-17 | Won | -0.4065 | -0.0000 |
| 16-Sep-06 | at Notre Dame (10) | 47-21 | Won | 2.0807 | 0.1751 |
| 23-Sep-06 | vs Wisconsin (6) | 27-13 | Won | 1.9353 | 0.0297 |
| 30-Sep-06 | at Minnesota (39) | 28-14 | Won | 0.7653 | -0.0000 |
| 07-Oct-06 | vs Michigan St (71) | 31-13 | Won | -0.5119 | -0.0000 |
| 14-Oct-06 | at Penn State (13) | 17-10 | Won | 1.6986 | -0.0000 |
| 21-Oct-06 | vs Iowa (48) | 20-6 | Won | -0.1152 | -0.0000 |
| 28-Oct-06 | vs Northwestern (78) | 17-3 | Won | -0.7172 | -0.0000 |
| 04-Nov-06 | vs Ball St (89) | 34-26 | Won | -1.0092 | -0.0000 |
| 11-Nov-06 | at Indiana (47) | 34-3 | Won | 0.3773 | -0.0000 |
| 18-Nov-06 | at Ohio State (1) | 39-42 | Lost | 3.7926 | -0.1129 |
A red opponent rating indicates modification according to home field advantage (0.2218).