| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Akron (102) | 34-16 | Won | -1.3584 | -0.0000 |
| 09-Sep-06 | at Notre Dame (10) | 17-41 | Lost | 2.0807 | -0.3961 |
| 23-Sep-06 | at Ohio State (1) | 6-28 | Lost | 3.7926 | 0.0000 |
| 30-Sep-06 | vs Northwestern (78) | 33-7 | Won | -0.7172 | -0.0000 |
| 07-Oct-06 | at Minnesota (39) | 28-27 | Won | 0.7653 | 0.2884 |
| 14-Oct-06 | vs Michigan (2) | 10-17 | Lost | 2.6837 | 0.0000 |
| 21-Oct-06 | vs Illinois (98) | 26-12 | Won | -1.2424 | -0.0000 |
| 28-Oct-06 | at Purdue (40) | 12-0 | Won | 0.7291 | 0.2523 |
| 04-Nov-06 | at Wisconsin (6) | 3-13 | Lost | 2.3789 | -0.0979 |
| 11-Nov-06 | vs Temple (116) | 47-0 | Won | -2.1469 | -0.0000 |
| 18-Nov-06 | vs Michigan St (71) | 17-13 | Won | -0.5119 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2218).