| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Kent St (94) | 44-0 | Won | -0.7598 | -0.0000 |
| 09-Sep-06 | at California (12) | 17-42 | Lost | 1.8622 | 0.0000 |
| 16-Sep-06 | vs Temple (116) | 62-0 | Won | -2.1469 | -0.0000 |
| 23-Sep-06 | at Purdue (40) | 21-27 | Lost | 0.7291 | -0.8143 |
| 30-Sep-06 | vs Michigan (2) | 14-28 | Lost | 2.6837 | 0.0000 |
| 07-Oct-06 | vs Penn State (13) | 27-28 | Lost | 1.2550 | -0.2884 |
| 14-Oct-06 | at Wisconsin (6) | 12-48 | Lost | 2.3789 | 0.0000 |
| 28-Oct-06 | at Ohio State (1) | 0-44 | Lost | 3.7926 | 0.0000 |
| 04-Nov-06 | vs Indiana (47) | 63-26 | Won | -0.0664 | 0.3902 |
| 11-Nov-06 | at Michigan St (71) | 31-18 | Won | -0.0682 | 0.3883 |
| 18-Nov-06 | vs Iowa (48) | 34-24 | Won | -0.1152 | 0.3414 |
A red opponent rating indicates modification according to home field advantage (0.2218).