| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | vs Miami OH (109) | 38-31 | Won | -1.7540 | -0.0000 |
| 16-Sep-06 | vs Ball St (89) | 38-28 | Won | -1.0092 | -0.0000 |
| 23-Sep-06 | vs Minnesota (39) | 27-21 | Won | 0.3216 | 0.8143 |
| 30-Sep-06 | at Notre Dame (10) | 21-35 | Lost | 2.0807 | 0.0000 |
| 07-Oct-06 | at Iowa (48) | 17-47 | Lost | 0.3285 | -1.0000 |
| 14-Oct-06 | at Northwestern (78) | 31-10 | Won | -0.2735 | 0.2192 |
| 21-Oct-06 | vs Wisconsin (6) | 3-24 | Lost | 1.9353 | 0.0000 |
| 28-Oct-06 | vs Penn State (13) | 0-12 | Lost | 1.2550 | -0.2523 |
| 04-Nov-06 | at Michigan St (71) | 17-15 | Won | -0.0682 | 0.4245 |
| 11-Nov-06 | at Illinois (98) | 42-31 | Won | -0.7988 | -0.0000 |
| 18-Nov-06 | vs Indiana (47) | 28-19 | Won | -0.0664 | 0.4263 |
| 25-Nov-06 | at Hawai`i (33) | 35-42 | Lost | 0.8913 | -0.6160 |
A red opponent rating indicates modification according to home field advantage (0.2218).