| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Rutgers (14) | 0-33 | Lost | 1.6347 | 0.0000 |
| 16-Sep-06 | vs Syracuse (70) | 21-31 | Lost | -0.5105 | -0.4899 |
| 23-Sep-06 | vs Iowa (48) | 7-24 | Lost | -0.1152 | -0.0946 |
| 30-Sep-06 | at Michigan St (71) | 23-20 | Won | -0.0682 | 1.0000 |
| 07-Oct-06 | vs Indiana (47) | 32-34 | Lost | -0.0664 | -0.0458 |
| 14-Oct-06 | vs Ohio U. (49) | 17-20 | Lost | -0.1696 | -0.1490 |
| 21-Oct-06 | at Penn State (13) | 12-26 | Lost | 1.6986 | 0.0000 |
| 28-Oct-06 | at Wisconsin (6) | 24-30 | Lost | 2.3789 | 0.0000 |
| 04-Nov-06 | vs Ohio State (1) | 10-17 | Lost | 3.3490 | 0.0000 |
| 11-Nov-06 | vs Purdue (40) | 31-42 | Lost | 0.2855 | 0.0000 |
| 18-Nov-06 | at Northwestern (78) | 16-27 | Lost | -0.2735 | -0.2530 |
A red opponent rating indicates modification according to home field advantage (0.2218).