| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Idaho (92) | 27-17 | Won | -1.1537 | 0.1363 |
| 09-Sep-06 | vs Eastern Michigan (111) | 52-20 | Won | -1.8869 | -0.0000 |
| 16-Sep-06 | at Pittsburgh (59) | 38-23 | Won | 0.1638 | 1.0000 |
| 23-Sep-06 | vs Notre Dame (10) | 37-40 | Lost | 1.6370 | 0.0000 |
| 30-Sep-06 | vs Illinois (98) | 20-23 | Lost | -1.2424 | -1.0000 |
| 07-Oct-06 | at Michigan (2) | 13-31 | Lost | 3.1274 | 0.0000 |
| 14-Oct-06 | vs Ohio State (1) | 7-38 | Lost | 3.3490 | 0.0000 |
| 21-Oct-06 | at Northwestern (78) | 41-38 | Won | -0.2735 | 1.0000 |
| 28-Oct-06 | at Indiana (47) | 21-46 | Lost | 0.3773 | -0.3327 |
| 04-Nov-06 | vs Purdue (40) | 15-17 | Lost | 0.2855 | -0.4245 |
| 11-Nov-06 | vs Minnesota (39) | 18-31 | Lost | 0.3216 | -0.3883 |
| 18-Nov-06 | at Penn State (13) | 13-17 | Lost | 1.6986 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2218).