| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Penn State (13) | 16-34 | Lost | 1.6986 | 0.0000 |
| 09-Sep-06 | at North Carolina St (99) | 20-17 | Won | -0.8589 | 1.0000 |
| 16-Sep-06 | at Central Michigan (63) | 21-24 | Lost | 0.0371 | 0.0000 |
| 23-Sep-06 | vs North Texas (113) | 33-13 | Won | -2.0020 | 0.1345 |
| 30-Sep-06 | at Kent St (94) | 15-37 | Lost | -0.7598 | -0.6232 |
| 07-Oct-06 | at Cincinnati (37) | 14-20 | Lost | 0.7802 | 0.0000 |
| 21-Oct-06 | vs Miami OH (109) | 24-13 | Won | -1.7540 | 0.3825 |
| 28-Oct-06 | at Toledo (104) | 20-35 | Lost | -0.9897 | -0.8532 |
| 04-Nov-06 | vs Bowling Green (112) | 35-28 | Won | -1.9917 | 0.1449 |
| 09-Nov-06 | vs Buffalo (115) | 31-16 | Won | -2.0846 | 0.0519 |
| 16-Nov-06 | at Ohio U. (49) | 7-17 | Lost | 0.2740 | 0.0000 |
| 24-Nov-06 | vs Western Michigan (64) | 0-17 | Lost | -0.4100 | -0.2734 |
A red opponent rating indicates modification according to home field advantage (0.2218).