| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Wisconsin (6) | 14-35 | Lost | 1.9353 | 0.0000 |
| 09-Sep-06 | vs Buffalo (115) | 48-40 | Won | -2.0846 | 0.6852 |
| 16-Sep-06 | at Florida Int'l (119) | 33-28 | Won | -2.6781 | 0.0917 |
| 23-Sep-06 | vs Kent St (94) | 3-38 | Lost | -1.2034 | -0.4336 |
| 30-Sep-06 | at Ohio U. (49) | 21-9 | Won | 0.2740 | 1.0000 |
| 07-Oct-06 | at Ohio State (1) | 7-35 | Lost | 3.7926 | 0.0000 |
| 14-Oct-06 | vs Eastern Michigan (111) | 24-21 | Won | -1.8869 | 0.8829 |
| 19-Oct-06 | at Central Michigan (63) | 14-31 | Lost | 0.0371 | 0.0000 |
| 28-Oct-06 | at Temple (116) | 14-28 | Lost | -1.7032 | -0.9334 |
| 04-Nov-06 | at Akron (102) | 28-35 | Lost | -0.9147 | -0.1449 |
| 15-Nov-06 | vs Miami OH (109) | 7-9 | Lost | -1.7540 | -0.9842 |
| 21-Nov-06 | at Toledo (104) | 21-31 | Lost | -0.9897 | -0.2199 |
A red opponent rating indicates modification according to home field advantage (0.2218).