| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Boston College (27) | 24-31 | Lost | 0.6642 | -0.1511 |
| 09-Sep-06 | at Michigan (2) | 17-41 | Lost | 3.1274 | 0.0000 |
| 16-Sep-06 | vs Akron (102) | 24-21 | Won | -1.3584 | -0.0000 |
| 23-Sep-06 | at Eastern Michigan (111) | 24-17 | Won | -1.4433 | -0.0000 |
| 30-Sep-06 | at Kentucky (32) | 36-45 | Lost | 0.9139 | 0.0000 |
| 07-Oct-06 | at Toledo (104) | 42-20 | Won | -0.9897 | 0.1950 |
| 14-Oct-06 | vs Ball St (89) | 18-7 | Won | -1.0092 | 0.1755 |
| 19-Oct-06 | vs Bowling Green (112) | 31-14 | Won | -1.9917 | -0.0000 |
| 04-Nov-06 | at Temple (116) | 42-26 | Won | -1.7032 | -0.0000 |
| 10-Nov-06 | vs Western Michigan (64) | 31-7 | Won | -0.4100 | 0.7748 |
| 17-Nov-06 | at Northern Illinois (81) | 10-31 | Lost | -0.2965 | -1.0000 |
| 24-Nov-06 | at Buffalo (115) | 55-28 | Won | -1.6410 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2218).