| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 08-Sep-06 | vs Pittsburgh (59) | 15-33 | Lost | -0.2799 | -1.0000 |
| 16-Sep-06 | at Ohio State (1) | 7-37 | Lost | 3.7926 | 0.0000 |
| 23-Sep-06 | at Virginia Tech (25) | 13-29 | Lost | 1.1624 | -0.3960 |
| 30-Sep-06 | vs Miami OH (109) | 24-10 | Won | -1.7540 | -0.0000 |
| 07-Oct-06 | vs Akron (102) | 20-14 | Won | -1.3584 | -0.0000 |
| 14-Oct-06 | at Louisville (16) | 17-23 | Lost | 1.4817 | -0.0766 |
| 22-Oct-06 | vs South Florida (44) | 23-6 | Won | 0.1245 | 0.5661 |
| 28-Oct-06 | vs Syracuse (70) | 17-3 | Won | -0.5105 | -0.0000 |
| 11-Nov-06 | at West Virginia (28) | 24-42 | Lost | 1.0815 | -0.4768 |
| 18-Nov-06 | vs Rutgers (14) | 30-11 | Won | 1.1911 | 1.0000 |
| 25-Nov-06 | at Connecticut (69) | 26-23 | Won | -0.0407 | 0.4010 |
A red opponent rating indicates modification according to home field advantage (0.2218).