| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (4) | 12-35 | Lost | 1.34 | 0.00 |
| 09-Sep-06 | vs Ohio U. (47) | 23-35 | Lost | -0.02 | -0.83 |
| 16-Sep-06 | vs Buffalo (110) | 31-13 | Won | -1.09 | 0.10 |
| 30-Sep-06 | at Ball St (76) | 40-28 | Won | -0.08 | 1.00 |
| 08-Oct-06 | at Miami OH (109) | 28-25 | Won | -0.69 | 0.49 |
| 14-Oct-06 | at Western Michigan (52) | 14-16 | Lost | 0.31 | -0.50 |
| 21-Oct-06 | vs Temple (111) | 43-21 | Won | -1.09 | 0.09 |
| 28-Oct-06 | at Iowa (57) | 14-24 | Lost | 0.22 | -0.59 |
| 07-Nov-06 | vs Toledo (97) | 13-17 | Lost | -0.75 | -1.00 |
| 17-Nov-06 | vs Central Michigan (38) | 31-10 | Won | 0.13 | 1.00 |
| 24-Nov-06 | at Eastern Michigan (114) | 27-0 | Won | -0.76 | 0.43 |
| 19-Dec-06 | at TCU (28) | 7-37 | Lost | 0.45 | -0.37 |
A red opponent rating indicates modification according to home field advantage (0.19).