| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Northwestern (77) | 3-21 | Lost | -0.48 | -0.59 |
| 09-Sep-06 | at Purdue (49) | 31-38 | Lost | 0.36 | 0.00 |
| 16-Sep-06 | vs Kent St (84) | 14-16 | Lost | -0.56 | -0.67 |
| 23-Sep-06 | at Syracuse (69) | 14-34 | Lost | 0.02 | -0.10 |
| 30-Sep-06 | at Cincinnati (30) | 10-24 | Lost | 0.60 | 0.00 |
| 08-Oct-06 | vs Northern Illinois (70) | 25-28 | Lost | -0.38 | -0.49 |
| 15-Oct-06 | at Buffalo (110) | 38-31 | Won | -0.70 | 1.00 |
| 21-Oct-06 | at Akron (86) | 13-24 | Lost | -0.21 | -0.32 |
| 28-Oct-06 | vs Ball St (76) | 17-20 | Lost | -0.47 | -0.58 |
| 04-Nov-06 | at Western Michigan (52) | 24-27 | Lost | 0.31 | 0.00 |
| 15-Nov-06 | at Bowling Green (106) | 9-7 | Won | -0.60 | 1.00 |
| 24-Nov-06 | vs Ohio U. (47) | 24-34 | Lost | -0.02 | -0.13 |
A red opponent rating indicates modification according to home field advantage (0.19).