| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 08-Sep-06 | vs Pittsburgh (58) | 15-33 | Lost | -0.17 | -1.00 |
| 16-Sep-06 | at Ohio State (4) | 7-37 | Lost | 1.34 | -0.06 |
| 23-Sep-06 | at Virginia Tech (24) | 13-29 | Lost | 0.76 | -0.64 |
| 30-Sep-06 | vs Miami OH (109) | 24-10 | Won | -1.08 | 0.00 |
| 07-Oct-06 | vs Akron (86) | 20-14 | Won | -0.60 | 0.00 |
| 14-Oct-06 | at Louisville (7) | 17-23 | Lost | 1.26 | -0.14 |
| 22-Oct-06 | vs South Florida (34) | 23-6 | Won | 0.17 | 0.77 |
| 28-Oct-06 | vs Syracuse (69) | 17-3 | Won | -0.37 | 0.22 |
| 11-Nov-06 | at West Virginia (10) | 24-42 | Lost | 1.09 | -0.31 |
| 18-Nov-06 | vs Rutgers (11) | 30-11 | Won | 0.69 | 1.00 |
| 25-Nov-06 | at Connecticut (74) | 26-23 | Won | -0.04 | 0.56 |
A red opponent rating indicates modification according to home field advantage (0.19).