| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (69) | 20-13 | Won | 0.02 | 0.99 |
| 16-Sep-06 | vs Iowa St (98) | 27-17 | Won | -0.78 | 0.19 |
| 23-Sep-06 | at Illinois (108) | 24-7 | Won | -0.63 | 0.34 |
| 30-Sep-06 | vs Ohio State (4) | 17-38 | Lost | 0.95 | -0.08 |
| 07-Oct-06 | vs Purdue (49) | 47-17 | Won | -0.03 | 0.94 |
| 14-Oct-06 | at Indiana (54) | 28-31 | Lost | 0.29 | -0.74 |
| 21-Oct-06 | at Michigan (5) | 6-20 | Lost | 1.29 | 0.00 |
| 28-Oct-06 | vs Northern Illinois (70) | 24-14 | Won | -0.38 | 0.59 |
| 04-Nov-06 | vs Northwestern (77) | 7-21 | Lost | -0.48 | -1.00 |
| 11-Nov-06 | vs Wisconsin (8) | 21-24 | Lost | 0.84 | -0.19 |
| 18-Nov-06 | at Minnesota (50) | 24-34 | Lost | 0.34 | -0.69 |
| 30-Dec-06 | at Texas (18) | 24-26 | Lost | 0.72 | -0.31 |
A red opponent rating indicates modification according to home field advantage (0.19).