| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Kent St (84) | 44-0 | Won | -0.17 | 0.69 |
| 09-Sep-06 | at California (12) | 17-42 | Lost | 1.04 | -0.10 |
| 16-Sep-06 | vs Temple (111) | 62-0 | Won | -1.09 | 0.00 |
| 23-Sep-06 | at Purdue (49) | 21-27 | Lost | 0.36 | -0.78 |
| 30-Sep-06 | vs Michigan (5) | 14-28 | Lost | 0.90 | -0.24 |
| 07-Oct-06 | vs Penn State (23) | 27-28 | Lost | 0.39 | -0.75 |
| 14-Oct-06 | at Wisconsin (8) | 12-48 | Lost | 1.23 | 0.00 |
| 28-Oct-06 | at Ohio State (4) | 0-44 | Lost | 1.34 | 0.00 |
| 04-Nov-06 | vs Indiana (54) | 63-26 | Won | -0.10 | 0.76 |
| 11-Nov-06 | at Michigan St (78) | 31-18 | Won | -0.11 | 0.75 |
| 18-Nov-06 | vs Iowa (57) | 34-24 | Won | -0.17 | 0.69 |
| 29-Dec-06 | at Texas Tech (40) | 41-44 | Lost | 0.25 | -0.89 |
A red opponent rating indicates modification according to home field advantage (0.19).