| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Idaho (95) | 27-17 | Won | -0.72 | 0.58 |
| 09-Sep-06 | vs Eastern Michigan (114) | 52-20 | Won | -1.15 | 0.15 |
| 16-Sep-06 | at Pittsburgh (58) | 38-23 | Won | 0.22 | 1.00 |
| 23-Sep-06 | vs Notre Dame (16) | 37-40 | Lost | 0.56 | -0.14 |
| 30-Sep-06 | vs Illinois (108) | 20-23 | Lost | -1.02 | -1.00 |
| 07-Oct-06 | at Michigan (5) | 13-31 | Lost | 1.29 | 0.00 |
| 14-Oct-06 | vs Ohio State (4) | 7-38 | Lost | 0.95 | 0.00 |
| 21-Oct-06 | at Northwestern (77) | 41-38 | Won | -0.09 | 1.00 |
| 28-Oct-06 | at Indiana (54) | 21-46 | Lost | 0.29 | -0.41 |
| 04-Nov-06 | vs Purdue (49) | 15-17 | Lost | -0.03 | -0.73 |
| 11-Nov-06 | vs Minnesota (50) | 18-31 | Lost | -0.05 | -0.75 |
| 18-Nov-06 | at Penn State (23) | 13-17 | Lost | 0.78 | 0.00 |
A red opponent rating indicates modification according to home field advantage (0.19).