| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Rutgers (11) | 0-33 | Lost | 1.08 | 0.00 |
| 16-Sep-06 | vs Syracuse (69) | 21-31 | Lost | -0.37 | -0.55 |
| 23-Sep-06 | vs Iowa (57) | 7-24 | Lost | -0.17 | -0.34 |
| 30-Sep-06 | at Michigan St (78) | 23-20 | Won | -0.11 | 1.00 |
| 07-Oct-06 | vs Indiana (54) | 32-34 | Lost | -0.10 | -0.27 |
| 14-Oct-06 | vs Ohio U. (47) | 17-20 | Lost | -0.02 | -0.19 |
| 21-Oct-06 | at Penn State (23) | 12-26 | Lost | 0.78 | 0.00 |
| 28-Oct-06 | at Wisconsin (8) | 24-30 | Lost | 1.23 | 0.00 |
| 04-Nov-06 | vs Ohio State (4) | 10-17 | Lost | 0.95 | 0.00 |
| 11-Nov-06 | vs Purdue (49) | 31-42 | Lost | -0.03 | -0.21 |
| 18-Nov-06 | at Northwestern (77) | 16-27 | Lost | -0.09 | -0.26 |
A red opponent rating indicates modification according to home field advantage (0.19).