| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Western Michigan (52) | 39-20 | Won | -0.08 | 0.82 |
| 09-Sep-06 | at Ball St (76) | 24-23 | Won | -0.08 | 0.82 |
| 23-Sep-06 | vs Connecticut (74) | 7-14 | Lost | -0.43 | -1.00 |
| 30-Sep-06 | vs Wisconsin (8) | 17-52 | Lost | 0.84 | -0.26 |
| 07-Oct-06 | at Illinois (108) | 34-32 | Won | -0.63 | 0.27 |
| 14-Oct-06 | vs Iowa (57) | 31-28 | Won | -0.17 | 0.74 |
| 21-Oct-06 | at Ohio State (4) | 3-44 | Lost | 1.34 | 0.00 |
| 28-Oct-06 | vs Michigan St (78) | 46-21 | Won | -0.50 | 0.41 |
| 04-Nov-06 | at Minnesota (50) | 26-63 | Lost | 0.34 | -0.76 |
| 11-Nov-06 | vs Michigan (5) | 3-34 | Lost | 0.90 | -0.20 |
| 18-Nov-06 | at Purdue (49) | 19-28 | Lost | 0.36 | -0.74 |
A red opponent rating indicates modification according to home field advantage (0.19).