| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Boston College (14) | 24-31 | Lost | 0.61 | -0.72 |
| 09-Sep-06 | at Michigan (5) | 17-41 | Lost | 1.29 | -0.04 |
| 16-Sep-06 | vs Akron (86) | 24-21 | Won | -0.60 | 0.07 |
| 23-Sep-06 | at Eastern Michigan (114) | 24-17 | Won | -0.76 | 0.00 |
| 30-Sep-06 | at Kentucky (25) | 36-45 | Lost | 0.69 | -0.64 |
| 07-Oct-06 | at Toledo (97) | 42-20 | Won | -0.36 | 0.31 |
| 14-Oct-06 | vs Ball St (76) | 18-7 | Won | -0.47 | 0.20 |
| 19-Oct-06 | vs Bowling Green (106) | 31-14 | Won | -0.99 | 0.00 |
| 04-Nov-06 | at Temple (111) | 42-26 | Won | -0.70 | 0.00 |
| 10-Nov-06 | vs Western Michigan (52) | 31-7 | Won | -0.08 | 0.59 |
| 17-Nov-06 | at Northern Illinois (70) | 10-31 | Lost | 0.01 | -1.00 |
| 24-Nov-06 | at Buffalo (110) | 55-28 | Won | -0.70 | 0.00 |
| 30-Nov-06 | vs Ohio U. (47) | 31-10 | Won | 0.17 | 0.84 |
| 26-Dec-06 | vs Middle Tennessee St (56) | 31-14 | Won | 0.04 | 0.71 |
A red opponent rating indicates modification according to home field advantage (0.19).