| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Akron (86) | 34-16 | Won | -0.7121 | -0.0000 |
| 09-Sep-06 | at Notre Dame (4) | 17-41 | Lost | 1.6503 | -0.3891 |
| 23-Sep-06 | at Ohio State (1) | 6-28 | Lost | 2.4191 | 0.0000 |
| 30-Sep-06 | vs Northwestern (73) | 33-7 | Won | -0.5109 | -0.0000 |
| 07-Oct-06 | at Minnesota (32) | 28-27 | Won | 0.7133 | 0.6740 |
| 14-Oct-06 | vs Michigan (2) | 10-17 | Lost | 1.7731 | -0.2662 |
| 21-Oct-06 | vs Illinois (101) | 26-12 | Won | -1.0499 | -0.0000 |
| 28-Oct-06 | at Purdue (31) | 12-0 | Won | 0.7400 | 0.7006 |
| 04-Nov-06 | at Wisconsin (5) | 3-13 | Lost | 1.6487 | -0.3906 |
| 11-Nov-06 | vs Temple (112) | 47-0 | Won | -1.3759 | -0.0000 |
| 18-Nov-06 | vs Michigan St (65) | 17-13 | Won | -0.3649 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2077).