| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Kent St (79) | 44-0 | Won | -0.1934 | 0.3010 |
| 09-Sep-06 | at California (16) | 17-42 | Lost | 1.2460 | -0.2597 |
| 16-Sep-06 | vs Temple (112) | 62-0 | Won | -1.3759 | -0.0000 |
| 23-Sep-06 | at Purdue (31) | 21-27 | Lost | 0.7400 | -0.7656 |
| 30-Sep-06 | vs Michigan (2) | 14-28 | Lost | 1.7731 | 0.0000 |
| 07-Oct-06 | vs Penn State (15) | 27-28 | Lost | 0.8317 | -0.6740 |
| 14-Oct-06 | at Wisconsin (5) | 12-48 | Lost | 1.6487 | 0.0000 |
| 28-Oct-06 | at Ohio State (1) | 0-44 | Lost | 2.4191 | 0.0000 |
| 04-Nov-06 | vs Indiana (44) | 63-26 | Won | 0.0442 | 0.5385 |
| 11-Nov-06 | at Michigan St (65) | 31-18 | Won | 0.0505 | 0.5449 |
| 18-Nov-06 | vs Iowa (48) | 34-24 | Won | -0.0196 | 0.4748 |
A red opponent rating indicates modification according to home field advantage (0.2077).