| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Vanderbilt (82) | 27-7 | Won | -0.6343 | -0.0000 |
| 09-Sep-06 | vs Central Michigan (58) | 41-17 | Won | -0.1689 | -0.0000 |
| 16-Sep-06 | at Notre Dame (4) | 47-21 | Won | 1.6503 | 0.6695 |
| 23-Sep-06 | vs Wisconsin (5) | 27-13 | Won | 1.2333 | 0.2525 |
| 30-Sep-06 | at Minnesota (32) | 28-14 | Won | 0.7133 | -0.0000 |
| 07-Oct-06 | vs Michigan St (65) | 31-13 | Won | -0.3649 | -0.0000 |
| 14-Oct-06 | at Penn State (15) | 17-10 | Won | 1.2471 | 0.2662 |
| 21-Oct-06 | vs Iowa (48) | 20-6 | Won | -0.0196 | -0.0000 |
| 28-Oct-06 | vs Northwestern (73) | 17-3 | Won | -0.5109 | -0.0000 |
| 04-Nov-06 | vs Ball St (88) | 34-26 | Won | -0.7204 | -0.0000 |
| 11-Nov-06 | at Indiana (44) | 34-3 | Won | 0.4596 | -0.0000 |
| 18-Nov-06 | at Ohio State (1) | 39-42 | Lost | 2.4191 | -0.5618 |
A red opponent rating indicates modification according to home field advantage (0.2077).