| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | vs Boston College (13) | 24-31 | Lost | 0.8539 | -0.1850 |
| 09-Sep-06 | at Michigan (2) | 17-41 | Lost | 2.1885 | 0.0000 |
| 16-Sep-06 | vs Akron (86) | 24-21 | Won | -0.7121 | 0.2491 |
| 23-Sep-06 | at Eastern Michigan (110) | 24-17 | Won | -0.8792 | 0.0820 |
| 30-Sep-06 | at Kentucky (33) | 36-45 | Lost | 0.6482 | -0.3906 |
| 07-Oct-06 | at Toledo (103) | 42-20 | Won | -0.6389 | 0.3223 |
| 14-Oct-06 | vs Ball St (88) | 18-7 | Won | -0.7204 | 0.2408 |
| 19-Oct-06 | vs Bowling Green (107) | 31-14 | Won | -1.2179 | -0.0000 |
| 04-Nov-06 | at Temple (112) | 42-26 | Won | -0.9605 | 0.0007 |
| 10-Nov-06 | vs Western Michigan (62) | 31-7 | Won | -0.2682 | 0.6930 |
| 17-Nov-06 | at Northern Illinois (71) | 10-31 | Lost | -0.0879 | -1.0000 |
A red opponent rating indicates modification according to home field advantage (0.2077).