| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (1) | 12-35 | Lost | 2.4191 | 0.0000 |
| 09-Sep-06 | vs Ohio U. (45) | 23-35 | Lost | 0.0437 | -0.6607 |
| 16-Sep-06 | vs Buffalo (113) | 31-13 | Won | -1.4114 | -0.0000 |
| 30-Sep-06 | at Ball St (88) | 40-28 | Won | -0.3050 | 0.9906 |
| 08-Oct-06 | at Miami OH (109) | 28-25 | Won | -0.8532 | 0.4424 |
| 14-Oct-06 | at Western Michigan (62) | 14-16 | Lost | 0.1472 | -0.5572 |
| 21-Oct-06 | vs Temple (112) | 43-21 | Won | -1.3759 | -0.0000 |
| 28-Oct-06 | at Iowa (48) | 14-24 | Lost | 0.3958 | -0.3086 |
| 07-Nov-06 | vs Toledo (103) | 13-17 | Lost | -1.0543 | -1.0000 |
| 17-Nov-06 | vs Central Michigan (58) | 31-10 | Won | -0.1689 | 1.0000 |
A red opponent rating indicates modification according to home field advantage (0.2077).