| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (69) | 20-13 | Won | -0.0349 | 0.7769 |
| 16-Sep-06 | vs Iowa St (99) | 27-17 | Won | -0.9808 | -0.0000 |
| 23-Sep-06 | at Illinois (101) | 24-7 | Won | -0.6345 | 0.1773 |
| 30-Sep-06 | vs Ohio State (1) | 17-38 | Lost | 2.0037 | 0.0000 |
| 07-Oct-06 | vs Purdue (31) | 47-17 | Won | 0.3246 | 1.0000 |
| 14-Oct-06 | at Indiana (44) | 28-31 | Lost | 0.4596 | -0.7286 |
| 21-Oct-06 | at Michigan (2) | 6-20 | Lost | 2.1885 | 0.0000 |
| 28-Oct-06 | vs Northern Illinois (71) | 24-14 | Won | -0.5033 | 0.3086 |
| 04-Nov-06 | vs Northwestern (73) | 7-21 | Lost | -0.5109 | -1.0000 |
| 11-Nov-06 | vs Wisconsin (5) | 21-24 | Lost | 1.2333 | 0.0000 |
| 18-Nov-06 | at Minnesota (32) | 24-34 | Lost | 0.7133 | -0.4748 |
A red opponent rating indicates modification according to home field advantage (0.2077).