| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Rutgers (9) | 0-33 | Lost | 1.3875 | 0.0000 |
| 16-Sep-06 | vs Syracuse (69) | 21-31 | Lost | -0.4503 | -0.6081 |
| 23-Sep-06 | vs Iowa (48) | 7-24 | Lost | -0.0196 | -0.1773 |
| 30-Sep-06 | at Michigan St (65) | 23-20 | Won | 0.0505 | 1.0000 |
| 07-Oct-06 | vs Indiana (44) | 32-34 | Lost | 0.0442 | -0.1136 |
| 14-Oct-06 | vs Ohio U. (45) | 17-20 | Lost | 0.0437 | -0.1140 |
| 21-Oct-06 | at Penn State (15) | 12-26 | Lost | 1.2471 | 0.0000 |
| 28-Oct-06 | at Wisconsin (5) | 24-30 | Lost | 1.6487 | 0.0000 |
| 04-Nov-06 | vs Ohio State (1) | 10-17 | Lost | 2.0037 | 0.0000 |
| 11-Nov-06 | vs Purdue (31) | 31-42 | Lost | 0.3246 | 0.0000 |
| 18-Nov-06 | at Northwestern (73) | 16-27 | Lost | -0.0955 | -0.2532 |
A red opponent rating indicates modification according to home field advantage (0.2077).