| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (78) | 20-13 | Won | -0.2006 | 0.5652 |
| 16-Sep-06 | vs Iowa St (108) | 27-17 | Won | -1.2356 | -0.0000 |
| 23-Sep-06 | at Illinois (98) | 24-7 | Won | -0.5851 | 0.1807 |
| 30-Sep-06 | vs Ohio State (2) | 17-38 | Lost | 1.5521 | 0.0000 |
| 07-Oct-06 | vs Purdue (36) | 47-17 | Won | 0.2136 | 0.9794 |
| 14-Oct-06 | at Indiana (40) | 28-31 | Lost | 0.5227 | -0.7115 |
| 21-Oct-06 | at Michigan (1) | 6-20 | Lost | 2.3853 | 0.0000 |
| 28-Oct-06 | vs Northern Illinois (88) | 24-14 | Won | -0.7055 | 0.0603 |
| 04-Nov-06 | vs Northwestern (82) | 7-21 | Lost | -0.6331 | -1.0000 |
| 11-Nov-06 | vs Wisconsin (6) | 21-24 | Lost | 1.2774 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1961).