| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (2) | 12-35 | Lost | 1.9443 | 0.0000 |
| 09-Sep-06 | vs Ohio U. (44) | 23-35 | Lost | 0.0576 | -0.4329 |
| 16-Sep-06 | vs Buffalo (112) | 31-13 | Won | -1.4011 | 0.1083 |
| 30-Sep-06 | at Ball St (92) | 40-28 | Won | -0.4479 | 1.0000 |
| 08-Oct-06 | at Miami OH (114) | 28-25 | Won | -1.1427 | 0.3668 |
| 14-Oct-06 | at Western Michigan (60) | 14-16 | Lost | 0.2295 | -0.2611 |
| 21-Oct-06 | vs Temple (111) | 43-21 | Won | -1.3913 | 0.1181 |
| 28-Oct-06 | at Iowa (46) | 14-24 | Lost | 0.4303 | -0.0603 |
| 07-Nov-06 | vs Toledo (93) | 13-17 | Lost | -0.8482 | -1.0000 |
A red opponent rating indicates modification according to home field advantage (0.1961).