| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 08-Sep-06 | vs Pittsburgh (61) | 15-33 | Lost | -0.2259 | -1.0000 |
| 16-Sep-06 | at Ohio State (1) | 7-37 | Lost | 2.4191 | 0.0000 |
| 23-Sep-06 | at Virginia Tech (18) | 13-29 | Lost | 1.1040 | -0.2987 |
| 30-Sep-06 | vs Miami OH (109) | 24-10 | Won | -1.2686 | -0.0000 |
| 07-Oct-06 | vs Akron (86) | 20-14 | Won | -0.7121 | -0.0000 |
| 14-Oct-06 | at Louisville (12) | 17-23 | Lost | 1.3242 | -0.0785 |
| 22-Oct-06 | vs South Florida (49) | 23-6 | Won | -0.0360 | 0.5613 |
| 28-Oct-06 | vs Syracuse (69) | 17-3 | Won | -0.4503 | 0.1470 |
| 11-Nov-06 | at West Virginia (17) | 24-42 | Lost | 1.1991 | -0.2036 |
| 18-Nov-06 | vs Rutgers (9) | 30-11 | Won | 0.9721 | 1.0000 |
A red opponent rating indicates modification according to home field advantage (0.2077).