| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 31-Aug-06 | at Kent St (79) | 44-0 | Won | -0.2075 | 0.3634 |
| 09-Sep-06 | at California (10) | 17-42 | Lost | 1.2986 | -0.1304 |
| 16-Sep-06 | vs Temple (111) | 62-0 | Won | -1.3913 | -0.0000 |
| 23-Sep-06 | at Purdue (36) | 21-27 | Lost | 0.6058 | -0.8233 |
| 30-Sep-06 | vs Michigan (1) | 14-28 | Lost | 1.9931 | 0.0000 |
| 07-Oct-06 | vs Penn State (13) | 27-28 | Lost | 0.8460 | -0.5831 |
| 14-Oct-06 | at Wisconsin (6) | 12-48 | Lost | 1.6696 | 0.0000 |
| 28-Oct-06 | at Ohio State (2) | 0-44 | Lost | 1.9443 | 0.0000 |
| 04-Nov-06 | vs Indiana (40) | 63-26 | Won | 0.1305 | 0.7014 |
| 11-Nov-06 | at Michigan St (66) | 31-18 | Won | 0.0367 | 0.6076 |
A red opponent rating indicates modification according to home field advantage (0.1961).