| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | vs Akron (84) | 34-16 | Won | -0.6527 | -0.0000 |
| 09-Sep-06 | at Notre Dame (4) | 17-41 | Lost | 1.7443 | -0.2978 |
| 23-Sep-06 | at Ohio State (2) | 6-28 | Lost | 1.9443 | -0.0978 |
| 30-Sep-06 | vs Northwestern (82) | 33-7 | Won | -0.6331 | -0.0000 |
| 07-Oct-06 | at Minnesota (33) | 28-27 | Won | 0.6252 | 0.5831 |
| 14-Oct-06 | vs Michigan (1) | 10-17 | Lost | 1.9931 | -0.0490 |
| 21-Oct-06 | vs Illinois (98) | 26-12 | Won | -0.9773 | -0.0000 |
| 28-Oct-06 | at Purdue (36) | 12-0 | Won | 0.6058 | 0.5637 |
| 04-Nov-06 | at Wisconsin (6) | 3-13 | Lost | 1.6696 | -0.3726 |
| 11-Nov-06 | vs Temple (111) | 47-0 | Won | -1.3913 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1961).