| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (64) | 20-13 | Won | 0.0632 | 0.3782 |
| 16-Sep-06 | vs Iowa St (91) | 27-17 | Won | -1.0838 | -0.0000 |
| 23-Sep-06 | at Illinois (83) | 24-7 | Won | -0.2987 | 0.0163 |
| 30-Sep-06 | vs Ohio State (2) | 17-38 | Lost | 1.8719 | 0.0000 |
| 07-Oct-06 | vs Purdue (45) | 47-17 | Won | 0.0964 | 0.4114 |
| 14-Oct-06 | at Indiana (29) | 28-31 | Lost | 1.0009 | -0.6841 |
| 21-Oct-06 | at Michigan (1) | 6-20 | Lost | 2.7821 | 0.0000 |
| 28-Oct-06 | vs Northern Illinois (63) | 24-14 | Won | -0.4132 | -0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2405).