| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (2) | 12-35 | Lost | 2.3530 | 0.0000 |
| 09-Sep-06 | vs Ohio U. (39) | 23-35 | Lost | 0.2598 | -0.5675 |
| 16-Sep-06 | vs Buffalo (116) | 31-13 | Won | -1.8644 | -0.0000 |
| 30-Sep-06 | at Ball St (87) | 40-28 | Won | -0.4120 | 0.7606 |
| 08-Oct-06 | at Miami OH (113) | 28-25 | Won | -1.1809 | -0.0000 |
| 14-Oct-06 | at Western Michigan (44) | 14-16 | Lost | 0.6036 | -0.2238 |
| 21-Oct-06 | vs Temple (112) | 43-21 | Won | -1.6401 | -0.0000 |
| 28-Oct-06 | at Iowa (31) | 14-24 | Lost | 0.9255 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.2405).