| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 02-Sep-06 | at Ohio State (2) | 12-35 | Lost | 3.6528 | 0.0000 |
| 09-Sep-06 | vs Ohio U. (45) | 23-35 | Lost | -0.1165 | -0.6260 |
| 16-Sep-06 | vs Buffalo (112) | 31-13 | Won | -2.1450 | -0.0000 |
| 30-Sep-06 | at Ball St (89) | 40-28 | Won | -0.6820 | 0.8086 |
| 08-Oct-06 | at Miami OH (110) | 28-25 | Won | -1.4921 | -0.0000 |
| 14-Oct-06 | at Western Michigan (47) | 14-16 | Lost | 0.3553 | -0.1542 |
| 21-Oct-06 | vs Temple (111) | 43-21 | Won | -2.1425 | -0.0000 |
| 28-Oct-06 | at Iowa (46) | 14-24 | Lost | 0.4655 | -0.0440 |
A red opponent rating indicates modification according to home field advantage (0.3033).