| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 09-Sep-06 | at Syracuse (78) | 20-13 | Won | -0.3426 | 0.4952 |
| 16-Sep-06 | vs Iowa St (105) | 27-17 | Won | -1.8234 | -0.0000 |
| 23-Sep-06 | at Illinois (91) | 24-7 | Won | -0.7552 | 0.0825 |
| 30-Sep-06 | vs Ohio State (2) | 17-38 | Lost | 3.0462 | 0.0000 |
| 07-Oct-06 | vs Purdue (35) | 47-17 | Won | 0.2970 | 1.0000 |
| 14-Oct-06 | at Indiana (43) | 28-31 | Lost | 0.5457 | -0.6166 |
| 21-Oct-06 | at Michigan (1) | 6-20 | Lost | 4.0374 | 0.0000 |
| 28-Oct-06 | vs Northern Illinois (67) | 24-14 | Won | -0.7938 | 0.0440 |
| 04-Nov-06 | vs Northwestern (77) | 7-21 | Lost | -0.9466 | -1.0000 |
A red opponent rating indicates modification according to home field advantage (0.3033).