| Date | Opponent | Score | Result | Opp. Rating | Impact |
|---|---|---|---|---|---|
| 08-Sep-06 | vs Pittsburgh (56) | 15-33 | Lost | -0.1350 | -1.0000 |
| 16-Sep-06 | at Ohio State (2) | 7-37 | Lost | 1.9443 | 0.0000 |
| 23-Sep-06 | at Virginia Tech (26) | 13-29 | Lost | 0.8673 | -0.2701 |
| 30-Sep-06 | vs Miami OH (114) | 24-10 | Won | -1.5348 | -0.0000 |
| 07-Oct-06 | vs Akron (84) | 20-14 | Won | -0.6527 | 0.2099 |
| 14-Oct-06 | at Louisville (8) | 17-23 | Lost | 1.4601 | 0.0000 |
| 22-Oct-06 | vs South Florida (51) | 23-6 | Won | -0.0286 | 0.8339 |
| 28-Oct-06 | vs Syracuse (78) | 17-3 | Won | -0.5928 | 0.2698 |
| 11-Nov-06 | at West Virginia (14) | 24-42 | Lost | 1.2372 | 0.0000 |
A red opponent rating indicates modification according to home field advantage (0.1961).